کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10604619 | 982530 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of collagen-chondroitin sulfate-hyaluronic acid hybrid hydrogel scaffolds and cell compatibility in vitro
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ideal scaffolds for tissue engineering should mimic natural extracellular matrix (ECM) as much as possible. The aim of this study was to develop a biomimetic hydrogel scaffold with good operability and stability by collagen self-assembly. To improve physical and chemical performances, the hydrogels were crosslinked with different concentrations of genipin using gel-crosslinking method. Morphology, crosslinking index, and content of glycosaminoglycans of the hydrogel scaffolds were characterized. The potential of the hydrogels as cartilage tissue engineering scaffolds was evaluated by compression test, swelling measurement, in vitro degradation assay, and biocompatibility study in vitro. Results showed that hydrogel scaffold crosslinked with 0.75Â mM genipin exhibited balanced optimal properties, and excellent cellular compatibility. Since gelation was temperature sensitive and crosslink occurred under mild conditions, the hydrogel scaffold may be well suited as a carrier for chondrocytes transplantation or as cartilage tissue engineering scaffolds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 84, Issue 1, 11 February 2011, Pages 118-125
Journal: Carbohydrate Polymers - Volume 84, Issue 1, 11 February 2011, Pages 118-125
نویسندگان
Ling Zhang, Kuifeng Li, Wenqian Xiao, Li Zheng, Yumei Xiao, Hongsong Fan, Xingdong Zhang,