کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10604755 | 982530 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sustained release of ketoprofen from fibrous chitosan-poly(É-caprolactone) membranes
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chitosan-poly(É-caprolactone) was fabricated into drug-enclosed fibrous membranes by loading with ketoprofen and using a wet-spinning method. The optimized chitosan-poly(É-caprolactone) fibrous membranes with poly(É-caprolactone) proportions changing from about 20 to 40Â wt% showed notably enhanced tensile strength in wet state as compared to pure chitosan fibrous membranes. Some membranes loaded with an initial amount of around 8Â wt% ketoprofen were capable of maintaining sustained releases of ketoprofen for a period of time longer than 50Â h without significant initial burst release, and the corresponding release profiles could be effectively controlled by regulating the composition and diameters of the filaments. Kinetic analysis indicated that ketoprofen-release patterns from selected membranes were well fitted with Higuchi model and showed biphasic characteristics with different release-rate constants depending on the parameters of the membranes; and ketoprofen-releases were administrated by anomalous mechanisms involved both initial swelling and follow-up diffusion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 84, Issue 1, 11 February 2011, Pages 624-630
Journal: Carbohydrate Polymers - Volume 84, Issue 1, 11 February 2011, Pages 624-630
نویسندگان
Zheng Wang, Hua Wu, Chunyan Liao, Nuo Zhou, Wenze Cheng, Ying Wan,