کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10606099 | 982946 | 2006 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of octa- and dodecamers of d-ribitol-1-phosphate and their protein conjugates
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of octa- and dodecamers of d-ribitol-1-phosphate and their protein conjugates Synthesis of octa- and dodecamers of d-ribitol-1-phosphate and their protein conjugates](/preview/png/10606099.png)
چکیده انگلیسی
The bacterial cell-wall-associated teichoic acids contain predominantly d-ribitol residues interconnected by phosphodiester linkages. Because of their location, these antigens may be vaccine candidates as part of conjugate vaccines. Here, we describe the synthesis of extended oligomers of d-ribitol-1-phosphate linked to a spacer having an amino group at its terminus. The synthesis utilized a fully protected d-ribitol-phosphoramidite that was oligomerized in a stepwise fashion followed by deprotection. The free oligomers were connected to bovine serum albumin using oxime chemistry. Thus, the ribitol phosphate oligomers were converted into keto derivatives, and the albumin counterpart was decorated with aminooxy groups. Reaction of the functionalized saccharide and protein moieties afforded conjugates having up to 20 ribitol phosphate chains.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Research - Volume 341, Issue 12, 4 September 2006, Pages 2037-2048
Journal: Carbohydrate Research - Volume 341, Issue 12, 4 September 2006, Pages 2037-2048
نویسندگان
Anikó Fekete, Peter Hoogerhout, Gijsbert Zomer, Joanna Kubler-Kielb, Rachel Schneerson, John B. Robbins, Vince Pozsgay,