Self-organized thermo-responsive hydroxypropyl cellulose nanoparticles for curcumin delivery

► Cationic and anionic derivatives of hydroxypropyl cellulose were synthesized. ► The polymers self-assemble forming spherical nanoparticles. ► The size of the nanoparticles is temperature-dependent. ► Curcumin could be efficiently entrapped within the nanospheres. ► No burst effect was observed for curcumin release.