کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10613300 | 986879 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
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![عکس صفحه اول مقاله: Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier Micelle-like nanoparticles of star-branched PEO-PLA copolymers as chemotherapeutic carrier](/preview/png/10613300.png)
چکیده انگلیسی
Four-armed (star-branched) block copolymers of l-PLA and PEO were synthesized using ring opening polymerization with different LAÂ /Â EO ratio. Micellar aggregates were prepared from these block copolymers and characterized. Some surface segregation of PEG was found : the extent depends on the state of the material (whether it is in film or particle form), as well as on molecular geometry. The degradation behavior of star-shaped copolymer was studied over a three week period and compared to its linear counterpart. Anti-cancer drugs 5-FU and paclitaxel were loaded into the micellar nanoparticles. The drug release profile showed that the release of paclitaxel from these polymers could be controlled over 2 weeks. The kinetics of drug release for star-branched, tri- and di-block copolymers were compared. The micelles from star-shaped branch showed more complete release of drug than the diblock copolymers; also, the lower hydrodynamic radius of star-shaped polymers may result in better clearance of the carrier polymer from the body.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 110, Issue 1, 10 December 2005, Pages 20-33
Journal: Journal of Controlled Release - Volume 110, Issue 1, 10 December 2005, Pages 20-33
نویسندگان
Pan Jie, Subbu S. Venkatraman, Feng Min, Boey Yin Chiang Freddy, Gan Leong Huat,