کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10613390 | 986884 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro degradation and controlled release behavior of d,l-PLGA50 and PCL-b-d,l-PLGA50 copolymer microspheres
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Blank and bovine serum albumin (BSA)-loaded microspheres based on poly(lactic-acid-alt-glycolic acid) (d,l-PLGA50) and poly(ε-caprolactone)-b-poly(lactic-acid-alt-glycolic acid) (PCL-b-d,l-PLGA50) were successfully fabricated using water-in-oil-in-water (w/o/w) double-emulsion extraction/evaporation technique. In vitro degradation of the blank microspheres was characterized by techniques including nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The PCL-b-d,l-PLGA50 copolymer (Mn: number-average molecular weight, Mw: weight-average molecular weight, Mn = 44800, Mw / Mn = MWD = 1.24, ε-caprolactone (CL) % = 20.4% in molar ratio) had similar rate of molecular weight reduction compared with the d,l-PLGA50 copolymer before 5 weeks of in vitro degradation. The BSA % loading efficiency of microspheres was mainly controlled by both block copolymer composition and macromolecular architecture, while the sequence structure and the molecular weight of copolymer had no apparent effect on it. Significantly, The PCL-b-d,l-PLGA50 copolymer microspheres showed good release profiles with a nearly constant release during 20â110 days.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 107, Issue 1, 20 September 2005, Pages 53-64
Journal: Journal of Controlled Release - Volume 107, Issue 1, 20 September 2005, Pages 53-64
نویسندگان
Chang-Ming Dong, Ying-Zhi Guo, Kun-Yuan Qiu, Zhong-Wei Gu, Xin-De Feng,