کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10613572 986897 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergistic enhancement of testosterone transdermal delivery
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Synergistic enhancement of testosterone transdermal delivery
چکیده انگلیسی
In this study, the effects of occlusion, octisalate (OS), and propylene glycol (PG) on the in vitro skin permeability of testosterone (TES) have been investigated. TES (either alone or with OS 5% w/v) was applied as a finite dose to full-thickness neonatal porcine skin mounted in flow-through diffusion cells and the amount of TES appearing in the receptor solution (20% v/v ethanol) was determined over 24 h. The skin was occluded with a microscope glass cover slip and to determine the effect of PG, 400 μl of PG/water mixtures (of varying PG concentration) was applied. In addition, the effect of Solugel™ (a proprietary hydrogel containing PG 25% w/w) and Tegaderm™ (a semipermeable film dressing) on the permeation of TES was assessed. Occlusion had no effect on the permeation of TES, however, OS increased the flux of TES 2.9-fold. The concentration of PG which produced optimal TES flux was 20% v/v, and this concentration resulted in a 1.9-fold increase in TES permeation. By combining OS, PG, and occlusion, TES permeation was increased 8.7-fold, which was a synergistic enhancement. In addition, Solugel™ and Tegaderm™, when applied to the skin, produced a similar enhancement in TES permeation to that produced by PG 25% w/w and occlusion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 103, Issue 3, 18 April 2005, Pages 577-585
نویسندگان
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