کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10613577 | 986897 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Starch/Carbopol® spray-dried mixtures as excipients for oral sustained drug delivery
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present study evaluated if mixtures prepared by spray-drying an aqueous dispersion of Amioca® starch and Carbopol® 974P could be used as matrix for oral sustained drug delivery. The influence of the Amioca®/Carbopol® 974P ratio (0/100, 25/75, 50/50, 60/40, 85/15, 90/10, 95/5 and 100/0) and the pH and ionic strength (μ) of the dissolution medium on the drug release was investigated. The matrices composed of the spray-dried mixtures with 10% or 15% Carbopol® 974P sustained the drug release over the longest time period. At this Carbopol® concentration, shear viscosity measurements indicated the formation of an optimal network between the polymer chains of Amioca® starch and Carbopol® 974P, forming a rigid gel layer offering resistance to erosion during the dissolution experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 103, Issue 3, 18 April 2005, Pages 635-641
Journal: Journal of Controlled Release - Volume 103, Issue 3, 18 April 2005, Pages 635-641
نویسندگان
E. Pringels, D. Ameye, C. Vervaet, P. Foreman, J.P. Remon,