کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
106236 161534 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prostate cancer: the new evidence base for diagnosis and treatment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی قانونی
پیش نمایش صفحه اول مقاله
Prostate cancer: the new evidence base for diagnosis and treatment
چکیده انگلیسی

SummaryAlthough prostate cancer (PC) has a significant mortality, there is debate regarding the utility of PC screening. This debate continues as major studies investigating the value of population-based screening have yet to be concluded. Despite this, there is increasing evidence from preliminary reports from these series, as well as numerous others relating to outcome prediction for PC, that early detection leads to improved outcomes and a decrease in the burden of metastatic disease on our healthcare system.PC is rarely symptomatic until it has metastasised to bone and because of this PSA-based screening remains the only widely available and reliable method of diagnosis for organ-confined disease. There is now compelling evidence to show that:1.Cancers diagnosed by screening are more likely to be early stage, when most can be cured by a number of different treatment options.2.The maximum benefits of screening are for men aged 50-70 years. Older men have a greater chance of a clinically insignificant cancer being diagnosed for which treatment is not necessary.3.The familial risks of PC are well recognised. In particular, men with one or more first-degree relatives already diagnosed with the disease should be actively encouraged to undergo screening.4.Modern histopathological assessment of fine core needle biopsies of the prostate allows for the likely behaviour of cancer present to be accurately predicted. Changes that mimic those of malignancy can be confidently identified, so these cases are no longer incorrectly diagnosed. These improvements mean that now most men aged 5070 years diagnosed with PC will have clinically significant cancers that require treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 39, Issue 6, December 2007, Pages 537-544