Mortality response of folate receptor-activated, PEG-functionalized TiO2 nanoparticles for doxorubicin loading with and without ultraviolet irradiation

Results indicated that the effect of NPs on cancer cells killing is dose-dependent, optimized at 1.25 g/L. The performance of FA on the selective targeting was confirmed and maximized at FA/TiO2=0.5. As-optimized TiO2-PEG-FA-Dox conjugate, in comparison to pure Dox, was more effective as far as cancer cell viability reduced to about 5%, especially under UV irradiation.