کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
106475 161547 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adiponectin immunohistochemical expression in colorectal cancer and its correlation with histological grade and tumour microvessel density
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی قانونی
پیش نمایش صفحه اول مقاله
Adiponectin immunohistochemical expression in colorectal cancer and its correlation with histological grade and tumour microvessel density
چکیده انگلیسی

SummaryAimsAims: Adiponectin (ApN) is a 30 kDa adipo-cytokine with anti-angiogenic effects. The expression of its receptors, Adipo-R1 and Adipo-R2, has been reported in colorectal cancer tissue and cell lines, but ApN expression in this neoplasia has not been investigated until now. In the present study, we aimed to analyse ApN expression and its eventual correlations with the clinico-pathological parameters and with the quantity of neo-angiogenesis, as reflected by the microvessel density (MVD), in human sporadic surgically resected colorectal carcinomas.MethodsA total of 45 formalin-fixed, paraffin-embedded colorectal carcinomas were submitted to the immunohistochemical procedures for ApN and CD105, a specific marker for neo-angiogenesis which was used in the assessment of MVD.ResultsApN expression was evidenced in 12 of 45 colorectal carcinomas, and it was significantly associated with a high histological grade (p = 0.0002) and a low MVD count (p = 0.0471) of the tumours. No ApN immuno-expression was found in the epithelial cells lining the adjacent normal colorectal mucosa.ConclusionOur findings suggest an anti-angiogenic role for ApN in colorectal cancer. Nonetheless the significance of the prevalent expression of this cytokine in high-grade colorectal carcinomas needs to be elucidated before considering the use of ApN analogues as novel possible antitumour agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 41, Issue 6, October 2009, Pages 533-538