کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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106481 | 161547 | 2009 | 4 صفحه PDF | دانلود رایگان |

SummaryAimsSmooth muscle antibody (SMA) with F-actin reactivity has been reported as a diagnostic marker of autoimmune hepatitis. We re-visited this relationship by randomly selecting SMA-positive sera to test for reactivity with F-actin by ELISA. We correlated such reactivity with liver function testsMethodsSera positive for SMA by indirect immunofluorescence were tested for reactivity by F-actin ELISA and the results correlated with liver function tests.Results89 SMA-positive sera reacted with F-actin by ELISA. Of these, 35 (39%) had normal liver enzymes, while 54 (60%) had elevated liver enzymes. There was no difference between the groups with respect to age at presentation, female preponderance or presence of anti-nuclear antibody. In both groups, high titre SMA antibody predominantly with immunofluorescence staining of renal glomeruli and peritubular fibrils of renal tubules (‘G/T’ subset) correlated with makedly elevated F-actin values by ELISA. ‘Actin cables’ by immunofluorescence staining of Hep-2 cells were infrequently found in both groups.ConclusionThis is the first report of SMA with F-actin reactivity in subjects with normal liver function
Journal: Pathology - Volume 41, Issue 6, October 2009, Pages 572-575