کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
106481 161547 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
F-actin reactive smooth muscle antibody in subjects with normal liver function
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی قانونی
پیش نمایش صفحه اول مقاله
F-actin reactive smooth muscle antibody in subjects with normal liver function
چکیده انگلیسی

SummaryAimsSmooth muscle antibody (SMA) with F-actin reactivity has been reported as a diagnostic marker of autoimmune hepatitis. We re-visited this relationship by randomly selecting SMA-positive sera to test for reactivity with F-actin by ELISA. We correlated such reactivity with liver function testsMethodsSera positive for SMA by indirect immunofluorescence were tested for reactivity by F-actin ELISA and the results correlated with liver function tests.Results89 SMA-positive sera reacted with F-actin by ELISA. Of these, 35 (39%) had normal liver enzymes, while 54 (60%) had elevated liver enzymes. There was no difference between the groups with respect to age at presentation, female preponderance or presence of anti-nuclear antibody. In both groups, high titre SMA antibody predominantly with immunofluorescence staining of renal glomeruli and peritubular fibrils of renal tubules (‘G/T’ subset) correlated with makedly elevated F-actin values by ELISA. ‘Actin cables’ by immunofluorescence staining of Hep-2 cells were infrequently found in both groups.ConclusionThis is the first report of SMA with F-actin reactivity in subjects with normal liver function

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 41, Issue 6, October 2009, Pages 572-575