کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
106549 161557 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Staging bone marrow in diffuse large B-cell lymphoma: the role of ancillary investigations
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی قانونی
پیش نمایش صفحه اول مقاله
Staging bone marrow in diffuse large B-cell lymphoma: the role of ancillary investigations
چکیده انگلیسی

SummaryDiffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin's lymphoma (NHL) that requires treatment at initial diagnosis. Treatment decisions may be guided by staging investigations, which include assessment of bone marrow (BM). Traditionally this assessment has included light microscopic examination of the bone marrow aspirate and trephine biopsy. Ancillary testing—including immunophenotyping using flow cytometry on BM aspirates, immunohistochemistry (IHC) on BM trephines and molecular studies using immunoglobulin heavy (IgH) or light (IgL) chain gene rearrangements—are performed as required to aid histological diagnosis. This review examines the evidence for the routine use of ancillary tests in the initial staging of DLBCL, including the limitations, potential pitfalls and possible clinical implications of their use in this setting

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pathology - Volume 41, Issue 3, April 2009, Pages 214-222