کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10691031 1019576 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of the Uncertainty in Microbubble Characterization
ترجمه فارسی عنوان
تجزیه و تحلیل عدم قطعیت در تشخیص میکروبروی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم آکوستیک و فرا صوت
چکیده انگلیسی
There is increasing interest in the use of microbubble contrast agents for quantitative imaging applications such as perfusion and blood pressure measurement. The response of a microbubble to ultrasound excitation is, however, extremely sensitive to its size, the properties of its coating and the characteristics of the sound field and surrounding environment. Hence the results of microbubble characterization experiments can be significantly affected by experimental uncertainties, and this can limit their utility in predictive modelling. The aim of this study was to attempt to quantify these uncertainties and their influence upon measured microbubble characteristics. Estimates for the parameters characterizing the microbubble coating were obtained by fitting model data to numerical simulations of microbubble dynamics. The effect of uncertainty in different experimental parameters was gauged by modifying the relevant input values to the fitting process. The results indicate that even the minimum expected uncertainty in, for example, measurements of microbubble radius using conventional optical microscopy, leads to variations in the estimated coating parameters of ∼20%. This should be taken into account in designing microbubble characterization experiments and in the use of data obtained from them.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 42, Issue 6, June 2016, Pages 1412-1418
نویسندگان
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