کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10691639 1019602 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic Contrast-Enhanced Ultrasound of Slaughterhouse Porcine Livers in Machine Perfusion
ترجمه فارسی عنوان
اولتراسوند پیشرفته کنتراست پویا از کبد گوسفند کشتارگاه در پالایشگاه ماشین
کلمات کلیدی
تصویربرداری، کبد، کشتارگاه،
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم آکوستیک و فرا صوت
چکیده انگلیسی
The aim of this study was to enable investigations into novel imaging and surgical techniques by developing a readily accessible, versatile liver machine perfusion system. Slaughterhouse pig livers were used, and dynamic contrast-enhanced ultrasound was introduced to optimize the procurement process and provide real-time perfusion monitoring. The system comprised a single pump, oxygenator, bubble trap and two flowmeters for pressure-controlled perfusion of the vessels using an off-the-shelf perfusate at room temperature. Successful livers exhibited homogeneous perfusion in both the portal vein and hepatic artery with dynamic contrast-enhanced ultrasound, which correlated with stable oxygen uptake, bile production and hepatic resistance and normal histology at the end of 3 h of perfusion. Dynamic contrast-enhanced ultrasound revealed perfusion abnormalities invisible to the naked eye, thereby providing context to the otherwise systemic biochemical/hemodynamic measurements and focal biopsy findings. The model developed here is a simple, cost-effective approach for stable ex vivo whole-organ machine perfusion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 40, Issue 9, September 2014, Pages 2217-2230
نویسندگان
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