کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10691639 | 1019602 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamic Contrast-Enhanced Ultrasound of Slaughterhouse Porcine Livers in Machine Perfusion
ترجمه فارسی عنوان
اولتراسوند پیشرفته کنتراست پویا از کبد گوسفند کشتارگاه در پالایشگاه ماشین
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کلمات کلیدی
تصویربرداری، کبد، کشتارگاه،
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
چکیده انگلیسی
The aim of this study was to enable investigations into novel imaging and surgical techniques by developing a readily accessible, versatile liver machine perfusion system. Slaughterhouse pig livers were used, and dynamic contrast-enhanced ultrasound was introduced to optimize the procurement process and provide real-time perfusion monitoring. The system comprised a single pump, oxygenator, bubble trap and two flowmeters for pressure-controlled perfusion of the vessels using an off-the-shelf perfusate at room temperature. Successful livers exhibited homogeneous perfusion in both the portal vein and hepatic artery with dynamic contrast-enhanced ultrasound, which correlated with stable oxygen uptake, bile production and hepatic resistance and normal histology at the end of 3 h of perfusion. Dynamic contrast-enhanced ultrasound revealed perfusion abnormalities invisible to the naked eye, thereby providing context to the otherwise systemic biochemical/hemodynamic measurements and focal biopsy findings. The model developed here is a simple, cost-effective approach for stable ex vivo whole-organ machine perfusion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 40, Issue 9, September 2014, Pages 2217-2230
Journal: Ultrasound in Medicine & Biology - Volume 40, Issue 9, September 2014, Pages 2217-2230
نویسندگان
Maria-Louisa Izamis, Andreas Efstathiades, Christina Keravnou, Edward L. Leen, Michalakis A. Averkiou,