کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10692023 | 1019616 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thermal Fixation of Swine Liver Tissue after Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation1
ترجمه فارسی عنوان
رفع حرارتی بافت کبد خوکی پس از انفجار سونوگرافی متمرکز با شدت بالا هدایت رزونانس مغناطیسی
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کلمات کلیدی
سونوگرافی متمرکز با شدت بالا با رزونانس مغناطیسی، دفع کبد، مدل سوسیس، هیپرترمی، تثبیت حرارتی،
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
چکیده انگلیسی
The aim of this study was to investigate experimental conditions for efficient and controlled in vivo liver tissue ablation by magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) in a swine model, with the ultimate goal of improving clinical treatment outcome. Histological changes were examined both acutely (four animals) and 1 wk after treatment (five animals). Effects of acoustic power and multiple sonication cycles were investigated. There was good correlation between target size and observed ablation size by thermal dose calculation, post-procedural MR imaging and histopathology, when temperature at the focal point was kept below 90°C. Structural histopathology investigations revealed tissue thermal fixation in ablated regions. In the presence of cavitation, mechanical tissue destruction occurred, resulting in an ablation larger than the target. Complete extra-corporeal MR-guided HIFU ablation in the liver is feasible using high acoustic power. Nearby large vessels were preserved, which makes MR-guided HIFU promising for the ablation of liver tumors adjacent to large veins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 40, Issue 7, July 2014, Pages 1564-1577
Journal: Ultrasound in Medicine & Biology - Volume 40, Issue 7, July 2014, Pages 1564-1577
نویسندگان
Frédéric Courivaud, Airazat M. Kazaryan, Alice Lund, Vivian C. Orszagh, Aud Svindland, Irina Pavlik Marangos, Per Steinar Halvorsen, Peter Jebsen, Erik Fosse, Per Kristian Hol, Bjørn Edwin,