کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10693087 | 1019757 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of ultrasound operating parameters on ultrasound-induced thrombolysis in vitro
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
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چکیده انگلیسی
The effect of operating parameters on the thrombolytic potency of ultrasound (US) is important for potential therapeutic applications, but is not fully understood. Fresh human whole-blood thrombi were exposed in vitro to focused US from a diagnostic transducer driven by an impulse generator via an amplifier to vary duration (10 to 60 min), intensity (7 to 90 W/cm2), frequency (2 to 4.5 MHz), pulsed wave duty cycle (1:5 to 1:100 and continuous wave mode) and pulse length (100 to 400 μs). Segments of thrombi (498 ± 73 mg) were submersed and insonated in saline solution. Thrombolytic efficiency was expressed as percentage loss of mass compared with controls (noninsonified thrombi). Ultrasound exposure achieved a significantly higher thrombolysis than no US, 56 ± 16 % vs. 29 ± 11 % (n = 232, p < 10â6). There was an exponential saturation-type correlation with duration of insonation (r2 = 0.64) and intensity (r2 = 0.97), an inverse correlation with US frequency at matched intensities (r2 = 0.76, p < 10â5), a logarithmic relationship with duty cycle in pulsed mode (r2 = 0.86) and a modest direct effect of pulse length (r2 = 0.57, p < 10â5). Thus, thrombolytic efficiency of US depends directly on duration, intensity, duty cycle and pulse length and inversely, on frequency. (E-mail: frank.flachskampf@rzmail.uni-erlangen.de)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 31, Issue 6, June 2005, Pages 841-847
Journal: Ultrasound in Medicine & Biology - Volume 31, Issue 6, June 2005, Pages 841-847
نویسندگان
Simon Schäfer, Stefan Kliner, Lutz Klinghammer, Hans Kaarmann, Ivan Lucic, Uwe Nixdorff, Uri Rosenschein, Werner G. Daniel, Frank A. Flachskampf,