کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10693087 1019757 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of ultrasound operating parameters on ultrasound-induced thrombolysis in vitro
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
Influence of ultrasound operating parameters on ultrasound-induced thrombolysis in vitro
چکیده انگلیسی
The effect of operating parameters on the thrombolytic potency of ultrasound (US) is important for potential therapeutic applications, but is not fully understood. Fresh human whole-blood thrombi were exposed in vitro to focused US from a diagnostic transducer driven by an impulse generator via an amplifier to vary duration (10 to 60 min), intensity (7 to 90 W/cm2), frequency (2 to 4.5 MHz), pulsed wave duty cycle (1:5 to 1:100 and continuous wave mode) and pulse length (100 to 400 μs). Segments of thrombi (498 ± 73 mg) were submersed and insonated in saline solution. Thrombolytic efficiency was expressed as percentage loss of mass compared with controls (noninsonified thrombi). Ultrasound exposure achieved a significantly higher thrombolysis than no US, 56 ± 16 % vs. 29 ± 11 % (n = 232, p < 10−6). There was an exponential saturation-type correlation with duration of insonation (r2 = 0.64) and intensity (r2 = 0.97), an inverse correlation with US frequency at matched intensities (r2 = 0.76, p < 10−5), a logarithmic relationship with duty cycle in pulsed mode (r2 = 0.86) and a modest direct effect of pulse length (r2 = 0.57, p < 10−5). Thus, thrombolytic efficiency of US depends directly on duration, intensity, duty cycle and pulse length and inversely, on frequency. (E-mail: frank.flachskampf@rzmail.uni-erlangen.de)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 31, Issue 6, June 2005, Pages 841-847
نویسندگان
, , , , , , , , ,