کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10693092 | 1019757 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Three-dimensional ultrasound biomicroscopy for xenograft growth analysis
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Three-dimensional ultrasound biomicroscopy for xenograft growth analysis Three-dimensional ultrasound biomicroscopy for xenograft growth analysis](/preview/png/10693092.png)
چکیده انگلیسی
We reported the use of high-frequency ultrasound biomicroscopy (UBM) in the quantitative analysis of early tumor growth in mice bearing melanoma xenografts in a noninvasive longitudinal assay. Initially, measurements of tumor width, depth and length were obtained using on-screen UBM calipers in real time and tumor volume was calculated with the standard ellipsoid formula w d l Ï/6. We were able to detect initiating minute tumor nodules, with the lower limit of detection at â 0.01 mm3 in volume. Successive parallel cross-sectional UBM images (33 μm step) encompassing the complete length of these tumors were also obtained and reconstructed into 3-D representations. Subsequent segmentational volumetric analysis provided a measure of tumor volume. Volume measurements using the two techniques were highly correlated when all 33 xenografts were studied (r = 0.9813, p < 0.0001) and a lower degree of correlation was measured with a subset of early small tumors (r = 0.7973, n = 16, p = 0.0004). Further analysis demonstrated that 3-D segmentational volumetric analysis yielded volume estimates that were often smaller than the caliper-and-formula calculation for most early developing xenografts. Thus, 3-D UBM imaging and segmentation is expected to be especially valuable for small tumors that were observed to grow in irregular shapes other than ellipsoids. (E-mail: acheung@sten.sunnybrook.utoronto.ca)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 31, Issue 6, June 2005, Pages 865-870
Journal: Ultrasound in Medicine & Biology - Volume 31, Issue 6, June 2005, Pages 865-870
نویسندگان
Alison M.Y. Cheung, Allison S. Brown, Lauren A. Hastie, Viviene Cucevic, Marcia Roy, James C. Lacefield, Aaron Fenster, F. Stuart Foster,