کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10693186 | 1019762 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diclofenac phonophoresis in human volunteers
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
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چکیده انگلیسی
A quantitative study of sodium diclofenac (Voltaren Emulgel®, Novartis) phonophoresis was undertaken in humans. Fourteen healthy human volunteers were submitted to ultrasound irradiation on two 225-cm2 areas on the dorsum (group A), followed by the application of the medication gel, and the plasma diclofenac mass was measured at 1, 2 and 3 h later by high performance liquid chromatography. The same procedure was repeated one month later with the same volunteers but with the ultrasound equipment switched off for the control group (group B). The plasma diclofenac mass was significantly higher in group A than in group B at 1 h (0.0987 μg/mL as opposed to 0.0389 μg/mL; p = 0.01) and 2 h (0.0724 μg/mL as opposed to 0.0529 μg/mL; p = 0.01), but not at 3 h (0.0864 μg/mL as opposed to 0.0683 μg/mL; p = 0.16). The authors conclude that previously applied therapeutic ultrasound irradiation enhances the percutaneous penetration of the topical diclofenac gel, although the mechanism remains unclear. (E-mail: chbarbie@fmrp.usp.br)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 31, Issue 3, March 2005, Pages 337-343
Journal: Ultrasound in Medicine & Biology - Volume 31, Issue 3, March 2005, Pages 337-343
نویسندگان
Giovana C. Rosim, Cláudio Henrique Barbieri, Fernando Mauro Lanças, Nilton Mazzer,