PET-based quantification of statistical properties of hypoxic tumor subvolumes in head and neck cancer

Although hypoxia diminishes during chemoradiation, it is a major predictor of outcome. HF, if large enough, can be predicted from the median T/M SUV ratio. CT-delineated gross tumor size does not influence the percentage of hypoxic voxels. Primary tumors are less likely hypoxic at an earlier stage.