کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10731004 | 1042990 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radioprotective activity of Polyalthia longifolia standardized extract against X-ray radiation injury in mice
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The radioprotective effect of Polyalthia longifolia was studied in mice. P.âlongifolia treatment showed improvement in mice survival compared to 100% mortality in the irradiated mice. Significant increases in hemoglobin concentration, and red blood cell, white blood cell and platelet counts were observed in the animals pretreated with leaf extract. Pre-irradiation administration of P.âlongifolia leaf extract also increased the CFU counts of the spleen colony and increased the relative spleen size. A dose-dependent decrease in lipid peroxidation levels was observed in the animals pretreated with P.âlongifolia. However, although the animals pretreated with P.âlongifolia exhibited a significant increase in superoxide dismutase and catalase activity, the values remained below normal in both liver and the intestine. Pre-irradiation administration of P.âlongifolia also resulted in the regeneration of the mucosal crypts and villi of the intestine. Moreover, pretreatment with P.âlongifolia leaf extract also showed restoration of the normal liver cell structure and a significant reduction in the elevated levels of ALT, AST and bilirubin. These results suggested the radioprotective ability of P.âlongifolia leaf extract, which is significant for future investigation for human applications in developing efficient, economically viable, non-toxic natural and clinically acceptable novel radioprotectors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica Medica - Volume 32, Issue 1, January 2016, Pages 150-161
Journal: Physica Medica - Volume 32, Issue 1, January 2016, Pages 150-161
نویسندگان
Subramanion L. Jothy, Tamio Saito, Jagat R. Kanwar, Yeng Chen, Azlan Aziz, Leong Yin-Hui, Sreenivasan Sasidharan,