Honeybees and cell lines as models of DNA methylation and aging in response to diet

► DNA methylation is affected by diet and changes as we grow older. ► DNA methylation affects gene function, and so may be a link between diet and aging. ► We need good model systems to study and understand these likely interactions. ► Cell lines and animals provide useful models, but have drawbacks. ► The honeybee may offer several advantages over other more commonly-used models.