Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction

► Methionine restriction decreases mtROS production at complex I and mtDNA damage. ► Restriction of dietary protein can be the first (partial) DR-mimic for human beings. ► mtDNA is situated close to or even in contact with the site of mtROS generation. ► That disposition helps to control the longevity of the different animal species. ► A low rate of generation of endogenous damage is a main trait of long-lived animals.