Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent

► 7-Oxysterols induce p53, phospho-p53, and oxidative stress in apoptosis. ► Nuclear p53 and lysosomal and mitochondrial membrane permeabilization are induced in M1-t-p53 cells, but not in M1 cells. ► 7-Oxsyterols induce apoptosis via p53-dependent lysosomal-mitochondrial pathways.