کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10739123 | 1046862 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation
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کلمات کلیدی
3,5-dibromo-4-nitrosobenzenesulfonic acidLNO2DBNBSLC-ESI/MS/MSMGDSDSvasodilation - اتساع عروقNMR - تشدید مغناطیسی هستهای EPR - تشدید پارامغناطیس الکترونElectronic paramagnetic resonance - رزونانس پارامغناطیس الکترونیکsodium dodecyl sulfate - سدیم دودسیل سولفاتNuclear magnetic resonance spectroscopy - طیف سنجی رزونانس مغناطیسی هسته ایLinoleate - لینولئیتLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)Nitrogen dioxide - نیتروژن دیاکسیدLipid peroxidation - پراکسیداسیون لیپیدLiquid chromatography/electrospray ionization tandem mass spectrometry - کروماتوگرافی مایع / الکترو اسپری یونیزاسیون اسپکترومتری دو طرفهhigh-pressure liquid chromatography - کروماتوگرافی مایع با فشار بالاHPLC - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Nitric oxide-derived oxidants such as nitrogen dioxide and peroxynitrite have been receiving increasing attention as mediators of nitric oxide toxicity. Indeed, nitrated and nitrosated compounds have been detected in biological fluids and tissues of healthy subjects and in higher yields in patients under inflammatory or infectious conditions as a consequence of nitric oxide overproduction. Among them, nitrated lipids have been detected in vivo. Here, we confirmed and extended previous studies by demonstrating that nitrolinoleate, chlolesteryl nitrolinoleate, and nitrohydroxylinoleate induce vasorelaxation in a concentration-dependent manner while releasing nitric oxide that was characterized by chemiluminescence-and EPR-based methodologies. As we first show here, diffusible nitric oxide production is likely to occur by isomerization of the nitrated lipids to the corresponding nitrite derivatives that decay through homolysis and/or metal ion/ascorbate-assisted reduction. The homolytic mechanism was supported by EPR spin-trapping studies with 3,5-dibromo-4-nitrosobenzenesulfonic acid that trapped a lipid-derived radical during nitrolinoleate decomposition. In addition to provide a mechanism to explain nitric oxide production from nitrated lipids, the results support their role as endogenous sources of nitric oxide that may play a role in endothelium-independent vasorelaxation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 39, Issue 4, 15 August 2005, Pages 532-539
Journal: Free Radical Biology and Medicine - Volume 39, Issue 4, 15 August 2005, Pages 532-539
نویسندگان
Ãmersom S. Lima, Marcelo G. Bonini, Ohara Augusto, Hermes V. Barbeiro, Heraldo P. Souza, Dulcineia S.P. Abdalla,