کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10739578 | 1046881 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of the oxidation products of BO-653 formed during peroxyl radical-mediated oxidation of human plasma
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
HMBCCE-OOHα-TOHNOESYLDIBO-653PMCAAPHTMPESI-MSTocopherol-mediated peroxidationnuclear magnetic resonance - رزونانس مغناطیسی هستهای2,2′-azobis(2-amidinopropane) dihydrochloride - 2،2'-azobis (2-آمیدین پروپان) دی هیدروکلرایدα-Tocopherol - α-توکوفرولAntioxidant - آنتی اکسیدانElectrospray Ionization Mass Spectrometry - اسپکترومتر جرم یونیزاسیون ElectrosprayNMR - تشدید مغناطیسی هستهای Free radical - رادیکالهای آزاد Nuclear Overhauser enhancement spectroscopy - طیف سنجی افزایش هسته ای OverhauserLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال heteronuclear multiple-bond correlation - همبستگی چند باند هترو هسته ایLipid peroxidation - پراکسیداسیون لیپیدHuman plasma - پلاسمای انسانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
4,6-Di-tert-butyl-2,3-dihydro-2,2-dipentyl-5-benzofuranol (BO-653) is a novel antioxidant synthesized by theoretical findings and considerations. Here we report on the aqueous peroxyl radical-induced oxidation of human plasma in the presence of BO-653. When BO-653 was given to healthy human subjects at 400 mg twice daily for 28 days, lipids in the resulting plasma were protected from oxidation compared with lipids present in plasma from subjects receiving placebo. Similarly, BO-653 added in vitro at 50 μM inhibited the peroxyl radical-induced accumulation of cholesteryl ester hydroperoxides that occurred in the presence of α-tocopherol, although BO-653 did not decrease the rate of consumption of ascorbate, albumin-bound bilirubin, and uric acid. The antioxidant action of in vivo and in vitro added BO-653 was associated with the formation of two major reaction products of BO-653, the structures of which were elucidated by mass spectrometry and nuclear magnetic resonance analyses. The products were identified as stereoisomers of dioxybis(4,6-di-tert.-butyl-2,3,5,7a-tetrahydro-2,2-dipentylbenzofuran-5-one). These dialkylperoxides of BO-653 might be useful markers to assess the antioxidant function of BO-653 in biological systems in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 38, Issue 1, 1 January 2005, Pages 32-40
Journal: Free Radical Biology and Medicine - Volume 38, Issue 1, 1 January 2005, Pages 32-40
نویسندگان
Ryo Yamauchi, Peter Southwell-Keely, Cacang Suarna, Sangeeta Ray, Mark Raftery, Osamu Cynshi, Roland Stocker,