کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10748056 | 1050258 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin
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کلمات کلیدی
IAPXIAPNOX1NADPH oxidase 1 - NADPH اکسیداز 1Small interfering RNA - RNA تداخل کوچکROS - ROSsiRNA - siRNATransgenic - تراریختهBladder cancer - سرطان مثانهBBN - سوخت زیستیinhibitor of apoptosis protein - مهار کننده پروتئین آپوپتوزیسX-linked Inhibitor of Apoptosis Protein - پروتئین آپوپتوز وابسته به X-linkedTumor progression - پیشرفت تومورReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin](/preview/png/10748056.png)
چکیده انگلیسی
Human AlkB homolog 8 (ALKBH8) is highly expressed in high-grade, superficially and deeply invasive bladder cancer. Moreover, ALKBH8 knockdown induces apoptosis in bladder cancer cells. However, the underlying anti-apoptotic mechanism of ALKBH8 in bladder cancer cells has thus far remained unclear. Moreover, there is no direct evidence that highly expressed ALKBH8 is involved in tumor progression in vivo. We here show that ALKBH8 knockdown induced apoptosis via downregulating the protein expression of survivin, an anti-apoptotic factor also exhibiting increased levels in bladder cancer. We also clarify that ALKBH8 transgenic mice showed an accelerated rate of bladder tumor mass and invasiveness in an N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced bladder cancer model. These findings suggest that the high expression of ALKBH8 is critical for the growth and progression of bladder cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 477, Issue 3, 26 August 2016, Pages 413-418
Journal: Biochemical and Biophysical Research Communications - Volume 477, Issue 3, 26 August 2016, Pages 413-418
نویسندگان
Ikumi Ohshio, Ryoji Kawakami, Yohei Tsukada, Kazuhiro Nakajima, Kaori Kitae, Tomoki Shimanoe, Yasuka Saigo, Hiroaki Hase, Yuko Ueda, Kentaro Jingushi, Kazutake Tsujikawa,