A new glycotoxins inhibitor attenuates insulin resistance in liver and fat cells

A novel glycotoxin inhibitor, URM-II-81, modulated key molecules of proximal and distal insulin signaling and hence alleviated glycotoxin mediated diminished insulin signaling. URM-II-81 also increased glycogen synthesis and glucose uptake in liver and fat cells, respectively. Novel derivative of isatin showed significant reduced receptor for AGEs (RAGE) expression, antioxidant activity and PKC-alpha activation, therefore; URM-II-81 reduced glycotoxin induced insulin resistance.287