کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10748138 | 1050264 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion
ترجمه فارسی عنوان
فاکتور رشد بافت همبند توسط گاسترین فعال شده و درگیر مهاجرت و تهاجم ناشی از گشتین است
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کلمات کلیدی
گاسترین، فاکتور رشد بافت همبند، سلول های اپیتلیال معده، مهاجرت، تهاجم،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Connective tissue growth factor (CTGF) has been reported in gastric adenocarcinoma and in carcinoid tumors. The aim of this study was to explore a possible link between CTGF and gastrin in gastric epithelial cells and to study the role of CTGF in gastrin induced migration and invasion of AGS-GR cells. The effects of gastrin were studied using RT-qPCR, Western blot and assays for migration and invasion. We report an association between serum gastrin concentrations and CTGF abundancy in the gastric corpus mucosa of hypergastrinemic subjects and mice. We found a higher expression of CTGF in gastric mucosa tissue adjacent to tumor compared to normal control tissue. We showed that gastrin induced expression of CTGF in gastric epithelial AGS-GR cells via MEK, PKC and PKB/AKT pathways. CTGF inhibited gastrin induced migration and invasion of AGS-GR cells. We conclude that CTGF expression is stimulated by gastrin and involved in remodeling of the gastric epithelium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 475, Issue 1, 17 June 2016, Pages 119-124
Journal: Biochemical and Biophysical Research Communications - Volume 475, Issue 1, 17 June 2016, Pages 119-124
نویسندگان
Sabin Bhandari, Ingunn Bakke, J. Kumar, Vidar Beisvag, Arne K. Sandvik, Liv Thommesen, Andrea Varro, Kristin G. Nørsett,