کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10748901 | 1050283 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification and functional characterization of a novel bipartite nuclear localization sequence in ARID1A
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification and functional characterization of a novel bipartite nuclear localization sequence in ARID1A Identification and functional characterization of a novel bipartite nuclear localization sequence in ARID1A](/preview/png/10748901.png)
چکیده انگلیسی
AT-rich interactive domain-containing protein 1A (ARID1A) is a recently identified nuclear tumor suppressor frequently altered in solid tumor malignancies. We have identified a bipartite-like nuclear localization sequence (NLS) that contributes to nuclear import of ARID1A not previously described. We functionally confirm activity using GFP constructs fused with wild-type or mutant NLS sequences. We further show that cyto-nuclear localized, bipartite NLS mutant ARID1A exhibits greater stability than nuclear-localized, wild-type ARID1A. Identification of this undescribed functional NLS within ARID1A contributes vital insights to rationalize the impact of ARID1A missense mutations observed in patient tumors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 469, Issue 1, 1 January 2016, Pages 114-119
Journal: Biochemical and Biophysical Research Communications - Volume 469, Issue 1, 1 January 2016, Pages 114-119
نویسندگان
Nicholas W. Bateman, Yutaka Shoji, Kelly A. Conrads, Kevin D. Stroop, Chad A. Hamilton, Kathleen M. Darcy, George L. Maxwell, John I. Risinger, Thomas P. Conrads,