کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10749233 1050286 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Irisin relaxes mouse mesenteric arteries through endothelium-dependent and endothelium-independent mechanisms
ترجمه فارسی عنوان
اریسین آرتروز های مزانتر موش را از طریق سازوکار وابسته به اندوتلیوم و مستقل از اندوتلیوم آرام می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
Irisin, a newly discovered myokine, has been shown to produce modest weight loss and improve glucose intolerance in mice. The purpose of this study was to investigate the effects of irisin on vascular activity and the mechanisms involved. Experiments were performed on mouse mesenteric arteries. We demonstrated that irisin induced relaxation in mesenteric arteries with or without endothelium in a concentration-dependent manner. It was further demonstrated that the irisin-induced vasorelaxation effects on endothelium-intact mesenteric arteries were reduced by pretreatment with Nω-nitro-l-arginine methyl ester (l-NAME) or 1H-[1, 2, 4] oxadizolo [4, 3-a] quinoxalin-1-one (ODQ). However, pretreatment with indomethacin (INDO), a nonselective cyclooxygenase inhibitor did not modulate irisin-induced relaxation. In addition, the contraction due to extracellular Ca2+ influx and intracellular Ca2+ release was also inhibited by irisin. In summary, these results suggested that the endothelium-dependent relaxation of irisin is mediated by the nitric oxide (NO)-guanosine 3′, 5′-cyclic phosphate (cGMP)-dependent pathway but not the prostaglandin I2 (PGI2)-cyclic adenosine monophosphate (cAMP)-dependent mechanism. Endothelium-independent relaxation may be depend on inhibiting Ca2+ influx through blocking VDCCs and intracellular Ca2+ release through both IP3R and RyR channels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 468, Issue 4, 25 December 2015, Pages 832-836
نویسندگان
, , , ,