کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10749484 | 1050291 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of activators of methionine sulfoxide reductases A and B
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کلمات کلیدی
DMFMSRRPETrxROS - ROSthioredoxin - تیرودوکسینDabs - دگرسانdimethylformamide - دی متیل فرمالیدMethionine sulfoxide - سیفوکسید متیونینmethionine sulfoxide reductases - متیونین سولفوکسید ردوکتازAlpha-1 proteinase inhibitor - مهار کننده پروتئیناز آلفا 1Myr - میرReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The methionine sulfoxide reductase (Msr) family of enzymes has been shown to protect cells against oxidative damage. The two major Msr enzymes, MsrA and MsrB, can repair oxidative damage to proteins due to reactive oxygen species, by reducing the methionine sulfoxide in proteins back to methionine. A role of MsrA in animal aging was first demonstrated in Drosophila melanogaster where transgenic flies over-expressing recombinant bovine MsrA had a markedly extended life span. Subsequently, MsrA was also shown to be involved in the life span extension in Caenorhabditis elegans. These results supported other studies that indicated up-regulation, or activation, of the normal cellular protective mechanisms that cells use to defend against oxidative damage could be an approach to treat age related diseases and slow the aging process. In this study we have identified, for the first time, compounds structurally related to the natural products fusaricidins that markedly activate recombinant bovine and human MsrA and human MsrB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 469, Issue 4, 22 January 2016, Pages 863-867
Journal: Biochemical and Biophysical Research Communications - Volume 469, Issue 4, 22 January 2016, Pages 863-867
نویسندگان
Predrag Cudic, Neelambari Joshi, Daphna Sagher, Brandon T. Williams, Maciej J. Stawikowski, Herbert Weissbach,