کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10749631 1050294 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity
چکیده انگلیسی
To investigate the role of CD in pancreatic acinar cells, which constitute the exocrine pancreas, we generated and examined mice specifically deficient for CD in pancreatic acinar cells. CD deficient mice showed normal pancreatic development and autophagic activity, although LC3-II, which is a marker of the autophagosome, accumulates in both physiological and pancreatitis conditions. Moreover, CD deficiency leads to accumulation of matured cathepsin B (CB) and cathepsin L (CL) which are members of the cysteine protease family. We therefore conclude that CD in pancreatic acinar cells is implicated in CB and CL degradation but not in autophagic activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 469, Issue 3, 15 January 2016, Pages 405-411
نویسندگان
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