UNC-51-like kinase 1 blocks S6k1 phosphorylation contributes to neurodegeneration in Parkinson's disease model in vitro

ULK1 acts to inhibit S6k1 phosphorylation at T389, leading to MN9D viability reduction under MPP+ treatment. These results provide evidence for a novel mechanism by which the ULK1 inhibit S6k1 T389 phosphorylation contributes to neurodegeneration in MPP+ treated-MN9D, and suggests a new therapeutic strategy for PD.