کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10752907 1050333 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multiple lysines combined in HIV-1 Vif determines the responsiveness to CBF-β
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Multiple lysines combined in HIV-1 Vif determines the responsiveness to CBF-β
چکیده انگلیسی
The Vif (viral infectivity factor) protein of human immunodeficiency virus type-1 (HIV-1) is critical for HIV-1 infectivity. CBF-β is required for HIV-1 Vif function, as it increases the steady-state level of the HIV-1 Vif protein to promote host restriction factor APOBEC3 degradation. However, the precise mechanism by which CBF-β promotes HIV-1 Vif levels remains unclear. In the present study, we provided evidences that CBF-β promoted steady-state levels of HIV-1 Vif by inhibiting the degradation of HIV-1 Vif through the proteasome pathway. Our results reveal a new mechanism by which a cellular protein supports viral infectivity by inhibiting viral protein degradation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 457, Issue 3, 13 February 2015, Pages 385-390
نویسندگان
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