کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10753072 1050335 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ferulic acid in combination with PARP inhibitor sensitizes breast cancer cells as chemotherapeutic strategy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Ferulic acid in combination with PARP inhibitor sensitizes breast cancer cells as chemotherapeutic strategy
چکیده انگلیسی
Homologous-recombination (HR)-dependent repair defective cells are hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. Combinations of defective HR pathway and PARP inhibitors have been an effective chemotherapeutic modality. We previously showed that knockdown of the WD40-repeat containing protein, Uaf1, causes an HR repair defect in mouse embryo fibroblast cells and therefore, increases sensitivity to PARP inhibitor, ABT-888. Similarly, here, we show that ferulic acid reduces HR repair, inhibits RAD 51 foci formation, and accumulates γ-H2AX in breast cancer cells. Moreover, ferulic acid, when combined with ABT-888, renders breast cancer cells become hypersensitive to ABT-888. Our study indicates that ferulic acid in combination with ABT-888 treatment may serve as an effective combination chemotherapeutic agent as a natural bioactive compound.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 458, Issue 3, 13 March 2015, Pages 520-524
نویسندگان
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