کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10754460 | 1050356 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CPuORF correlates with miRNA responsive elements on protein evolutionary rates
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: CPuORF correlates with miRNA responsive elements on protein evolutionary rates CPuORF correlates with miRNA responsive elements on protein evolutionary rates](/preview/png/10754460.png)
چکیده انگلیسی
miRNA is increasingly being recognized as a key regulator of metabolism in animals. A wealth of evidence has suggested that miRNA mainly binds 3ⲠUTR of mRNA and modulates the cell activities via repressing the mRNA translation. However, as the translation initiates at 5ⲠUTR, cis elements like upstream open reading frame (uORF) resided in 5ⲠUTR may also affect the translation efficiency or elongation. In this study, we performed a systematic analysis of miRNA responsive elements (MREs) and uORF of the same transcript in three model organisms (human, mouse, and Drosophila). Intriguingly, we found that the 3ⲠUTR length grew with the complexity of species (human > mouse > Drosophila), in sharp contrast with the invariability of 5ⲠUTR. Additionally, MRE number correlated well with the 3ⲠUTR length, while uORF number showed a weak correlation with the 5ⲠUTR length. Further, we found that human genes with conserved peptide upstream open reading frame (CPuORF) tend to have more MREs and lower evolutionary rates, which provides new insights into the correlation between UTR properties and translational control in animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 452, Issue 1, 12 September 2014, Pages 66-71
Journal: Biochemical and Biophysical Research Communications - Volume 452, Issue 1, 12 September 2014, Pages 66-71
نویسندگان
Wangxiong Hu, Tingzhang Wang, Yanmei Yang, Shu Zheng,