کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10755234 1050370 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lidamycin regulates p53 expression by repressing Oct4 transcription
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Lidamycin regulates p53 expression by repressing Oct4 transcription
چکیده انگلیسی
Antitumor antibiotic lidamycin (LDM) is widely used in the treatment of a variety of cancers. Here we demonstrated that LDM up-regulates the expression of the tumor suppressor p53 gene by repressing Oct4 transcription. We showed that low dose LDM-induced increase of p53 expression and decrease of Oct4 expression in P19 and HCT116-p53+/+ cells. Knockdown of Oct4 expression by siRNA led to activation of p53 in both cell lines, whereas ectopical expression of Oct4 significantly inhibited p53 expression in P19 cells. LDM-induced p53 activation was blocked by ectopical expression of Oct4.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 447, Issue 2, 2 May 2014, Pages 224-230
نویسندگان
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