کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10755249 | 1050370 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vascular endothelial growth factor-like and its receptor in a crustacean optic ganglia: A role in neuronal differentiation?
ترجمه فارسی عنوان
فاکتور رشد اندوتلیال عروقی و گیرنده آن در یک گانگلیس اپتیکی پوستی: نقش در تمایز عصبی چیست؟
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
The neural system appears before the vascular system in the phylogenetic tree. During evolution, vascular system generation takes advantage of the pre-existing vascular endothelial growth factor (VEGF) in order to form its networks. Nevertheless, the role of VEGF in neuronal and glial cells is not yet completely understood. In order to support the hypothesis of a neural role for VEGF, we searched for VEGF- and VEGF receptor (VEGFR)-like immunoreactivities (immunohisto/cytochemistry and Western blotting) in the eyestalk of the invertebrate Ucides cordatus (Crustacea, Brachyura, Ucididae). Our results showed that both neurons and glial cells expressed VEGF-immunoreactivity, and that VEGFR was evidenced in neural cells. This is the first report about the VEGF/VEGFR-like immunoreactivities in the nervous tissue of a crustacean, and enables U. cordatus to be included in the repertoire of animal models used for ascertaining the role of VEGF in the nervous system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 447, Issue 2, 2 May 2014, Pages 299-303
Journal: Biochemical and Biophysical Research Communications - Volume 447, Issue 2, 2 May 2014, Pages 299-303
نویسندگان
Maria Alice Fusco, Inês Júlia Ribas Wajsenzon, Sergio Luiz de Carvalho, Rosilane Taveira da Silva, Marcelo Einicker-Lamas, Leny A. Cavalcante, Silvana Allodi,