کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10755298 1050372 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibiotic drug tigecycline inhibited cell proliferation and induced autophagy in gastric cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Antibiotic drug tigecycline inhibited cell proliferation and induced autophagy in gastric cancer cells
چکیده انگلیسی
Tigecycline acts as a glycylcycline class bacteriostatic agent, and actively resists a series of bacteria, specifically drug fast bacteria. However, accumulating evidence showed that tetracycline and their derivatives such as doxycycline and minocycline have anti-cancer properties, which are out of their broader antimicrobial activity. We found that tigecycline dramatically inhibited gastric cancer cell proliferation and provided an evidence that tigecycline induced autophagy but not apoptosis in human gastric cancer cells. Further experiments demonstrated that AMPK pathway was activated accompanied with the suppression of its downstream targets including mTOR and p70S6K, and ultimately induced cell autophagy and inhibited cell growth. So our data suggested that tigecycline might act as a candidate agent for pre-clinical evaluation in treatment of patients suffering from gastric cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 446, Issue 1, 28 March 2014, Pages 105-112
نویسندگان
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