Yin Yang 1 regulates the transcriptional repression of survivin

- YY1 overexpression resulted in survivin promoter repression in a luciferase system.
- YY1 knockdown using siRNA releases the survivin repression.
- Using a YY1 tet-off system, YY1 expression represses survivin expression.
- YY1 is capable of directly binding to the survivin promoter.