Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation

- CD44 variant8-10 and c-Myc are inversely expressed in gastric cancer cells.
- Redox-stress enhances c-Myc expression via canonical Wnt signal.
- CD44v, but not CD44 standard, suppresses redox stress-induced Wnt activation.
- CD44v expression promotes both transcription and proteasome degradation of c-Myc.
- Inversed expression pattern between CD44v and c-Myc is often recognized in vivo.