کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10756936 1050389 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth
چکیده انگلیسی
MTA2 is a member of metastasis associated family, which is highly expressed in several solid tumors and associated with tumor cells migration and invasion. Here, we report that MTA2 is acetylated at K152 and histone acetyltransferase p300 binds to and acetylates MTA2. Furthermore, mutation of the MTA2 acetylation site inhibits the growth of colorectal cancer cells and migration and invasion of Rat1 fibroblasts. These results reveal a novel post-translational regulation of MTA2 by the way of p300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for clinical cancer research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 444, Issue 3, 14 February 2014, Pages 387-390
نویسندگان
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