Unfolding protein response signaling is involved in development, maintenance, and regression of the corpus luteum during the bovine estrous cycle

- Unfolding protein responses (UPRs) are involved in natural bovine estrous cycle.
- ER stress-mediated apoptosis is induced in corpus luteum (CL) regression stage.
- During estrous cycle, functional link between UPRs signaling and CL life span.