کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10757955 | 1050401 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model
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کلمات کلیدی
PHDOIRVHLHREHIFAngiogenesis - آنژیوژنزVon Hippel–Lindau - از Hippel-Lindauintraperitoneal - داخل صفاقیRetinopathy - رتینوپاتیOxygen-induced retinopathy - رتینوپاتی ناشی از اکسیژنpostnatal day - روز پس از زایمانhypoxia response element - عنصر پاسخ هیپوکسیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Hypoxia Inducible Factor - فاکتور قابل تشخیص هیپوکسیTranscription regulation - مقررات رونویسیHonokiol - هونکیوول
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model Honokiol inhibits pathological retinal neovascularization in oxygen-induced retinopathy mouse model](/preview/png/10757955.png)
چکیده انگلیسی
Aberrant activation of the hypoxia inducible factor (HIF) pathway is the underlying cause of retinal neovascularization, one of the most common causes of blindness worldwide. The HIF pathway also plays critical roles during tumor angiogenesis and cancer stem cell transformation. We have recently shown that honokiol is a potent inhibitor of the HIF pathway in a number of cancer and retinal pigment epithelial cell lines. Here we evaluate the safety and efficacy of honokiol, digoxin, and doxorubicin, three recently identified HIF inhibitors from natural sources. Our studies show that honokiol has a better safety to efficacy profile as a HIF inhibitor than digoxin and doxorubicin. Further, we show for the first time that daily intraperitoneal injection of honokiol starting at postnatal day (P) 12 in an oxygen-induced retinopathy (OIR) mouse model significantly reduced retinal neovascularization at P17. Administration of honokiol also prevents the oxygen-induced central retinal vaso-obliteration, characteristic feature of the OIR model. Additionally, honokiol enhanced physiological revascularization of the retinal vascular plexuses. Since honokiol suppresses multiple pathways activated by HIF, in addition to the VEGF signaling, it may provide advantages over current treatments utilizing specific VEGF antagonists for ocular neovascular diseases and cancers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 438, Issue 4, 6 September 2013, Pages 697-702
Journal: Biochemical and Biophysical Research Communications - Volume 438, Issue 4, 6 September 2013, Pages 697-702
نویسندگان
Divya Teja Vavilala, Bliss E. O'Bryhim, V.K. Chaithanya Ponnaluri, R. Sid White, Jeff Radel, R.C. Andrew Symons, Mridul Mukherji,