کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10758032 | 1050402 | 2013 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In silico analysis of stomach lineage specific gene set expression pattern in gastric cancer
ترجمه فارسی عنوان
در تجزیه سیلیکا ژن اختصاصی ژن معیوب معده، الگوی بیان در سرطان معده قرار دارد
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کلمات کلیدی
SSPMsigDBDWDPGCIPAPIGCGCsGSEAER-αROCmGCSurvival - بقاGene Set Enrichment Analysis - تجزیه و تحلیل غنی سازی مجموعه ژنیDAVID - دیویدGastric cancer - سرطان معدهGastric cancers - سرطان معدهGene ontology - هستیشناسی ژنیDatabase for Annotation, Visualization, and Integrated Discovery - پایگاه داده برای علامت گذاری، تجسم، و کشف مجتمعreceiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Stomach lineage specific gene products act as a protective barrier in the normal stomach and their expression maintains the normal physiological processes, cellular integrity and morphology of the gastric wall. However, the regulation of stomach lineage specific genes in gastric cancer (GC) is far less clear. In the present study, we sought to investigate the role and regulation of stomach lineage specific gene set (SLSGS) in GC. SLSGS was identified by comparing the mRNA expression profiles of normal stomach tissue with other organ tissue. The obtained SLSGS was found to be under expressed in gastric tumors. Functional annotation analysis revealed that the SLSGS was enriched for digestive function and gastric epithelial maintenance. Employing a single sample prediction method across GC mRNA expression profiles identified the under expression of SLSGS in proliferative type and invasive type gastric tumors compared to the metabolic type gastric tumors. Integrative pathway activation prediction analysis revealed a close association between estrogen-α signaling and SLSGS expression pattern in GC. Elevated expression of SLSGS in GC is associated with an overall increase in the survival of GC patients. In conclusion, our results highlight that estrogen mediated regulation of SLSGS in gastric tumor is a molecular predictor of metabolic type GC and prognostic factor in GC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 439, Issue 4, 4 October 2013, Pages 539-546
Journal: Biochemical and Biophysical Research Communications - Volume 439, Issue 4, 4 October 2013, Pages 539-546
نویسندگان
Narayanan Sathiya Pandi, Sivagurunathan Suganya, Suriliyandi Rajendran,