The crystal structure of d-mandelate dehydrogenase reveals its distinct substrate and coenzyme recognition mechanisms from those of 2-ketopantoate reductase

- We firstly determined the crystal structure of d-mandelate dehydrogenase ManDH2.
- ManDH2 has a similar structure fold compared to 2-ketopantoate reductase.
- ManDH2 has unique coenzyme and substrate binding pockets.