Melatonin elevates apoptosis in human platelets via ROS mediated mitochondrial damage

- First report on the platelet toxic action of melatonin.
- Melatonin induces apoptosis by generation of ROS.
- Melatonin augments intracellular Ca2+ and damage mitochondria.
- Melatonin induces release of Cyt c and activate caspases and kinases.
- Finally, melatonin induces phosphatidyl serine exposure leading to apoptosis.