Identification of methyl violet 2B as a novel blocker of focal adhesion kinase signaling pathway in cancer cells

- FAK signaling cascade in cancer cells is profoundly inhibited by methyl violet 2B.
- Methyl violet 2B identified by virtual screening is a novel allosteric FAK inhibitor.
- Methyl violet 2B possesses extremely high kinase selectivity.
- Methyl violet 2B suppresses strongly the proliferation of cancer cells.
- Methyl violet 2B inhibits focal adhesion, invasion and migration of cancer cells.