Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages

Proposed AGMO function in modulation of macrophage PAF levels. Left panel, in resting conditions, AGMO expression is high and lyso-PAF is effectively degraded by AGMO. Right panel, after stimulation with LPS, AGMO levels decrease. Consequently, degradation of lyso-PAF is attenuated and PAF production is enhanced in activated macrophages.